Can we control cell migration modes?

Can we control how cells migrate by changing a single biochemical cue in their environment?
In our latest work, we used synthetic fibrous hydrogels to explore this question.
By presenting human stem cells with either an integrin-binding ligand (RGD), a cadherin-mimicking ligand (HAVDI), or no adhesive ligand, we were able to steer cells toward mesenchymal-like, hybrid, or amoeboid-like migration behaviors.

Importantly, these changes occurred without altering the bulk mechanics or architecture of the matrix.
Different ligands led to distinct adhesion structures, force transmission pathways, matrix remodeling patterns, and YAP activation, revealing how biochemical cues can shape migration strategy in 3D environments.
This work provides a simple and highly tunable platform to study migration plasticity and cell-matrix interactions in development, regeneration, and disease.

Congratulations to Haoxiang for leading the project and to all co-authors for their contributions!
🔎 Curious? Check it out here.