Live‐Cell SERS Endoscopy Using Plasmonic Nanowire Waveguides

Gang Lu, Herlinde De Keersmaecker, Liang Su, Bart Kenens, Susana Rocha, Eduard Fron, Chang Chen, Pol Van Dorpe, Hideaki Mizuno, Johan Hofkens, James A. Hutchison, Hiroshi Uji‐i (see publication in Journal )

Abstract

Live‐cell surface‐enhanced Raman spectroscopy (SERS) endoscopy is developed by using plasmonic nanowire waveguides as endoscopic probes. It is demonstrated that the probe insertion does not stress the cell. Opposed to conventional SERS endoscopy, with excitation at the hotspot within the cell, the remote excitation method yields low‐background SERS spectra from specific cell compartments with minimal associated photodamage.